Persistent proteomic alterations in the medial prefrontal cortex with abstinence from cocaine self-administration.

ABSTRACT: Neuroproteomic studies of drug abuse offer the potential for a systems-level understanding of addiction. Understanding cocaine-responsive alterations in brain protein expression that persist even with extended abstinence may provide insight into relapse liability. In the current study, protein changes in the medial prefrontal cortex of cocaine self-administering rats following 1 and 100 days of enforced abstinence were quantified by 2D-DIGE. We have previously reported increased drug-seeking and drug-taking, as well as mRNA and epigenetic changes in this model even after 100 days of enforced abstinence. A number of statistically-significant changes in proteins relating to synapse function and neuronal remodeling were evident, including neurofilament medium and heat shock protein 73 (Hsp73)

SUBMITTER: Lull ME 

PROVIDER: S-EPMC2742427 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature