Evidence for a shared nuclear pore complex architecture that is conserved from the last common eukaryotic ancestor.

ABSTRACT: The nuclear pore complex (NPC) is a macromolecular assembly embedded within the nuclear envelope that mediates bidirectional exchange of material between the nucleus and cytoplasm. Our recent work on the yeast NPC has revealed a simple modularity in its architecture and suggested a common evolutionary origin of the NPC and vesicle coating complexes in a progenitor protocoatomer. However, detailed compositional and structural information is currently only available for vertebrate and yeast NPCs, which are evolutionarily closely related. Hence our understanding of NPC composition in a full evolutionary context is sparse. Moreover despite the ubiquitous nature of the NPC, sequence searches in distant taxa have identified surprisingly few NPC components, suggesting that much of the NPC may not

SUBMITTER: DeGrasse JA 

PROVIDER: S-EPMC2742445 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature