Spatial phylodynamics of HIV-1 epidemic emergence in east Africa.

ABSTRACT:

Design

We sought to investigate the evolutionary and historical reasons for the different epidemiological patterns of HIV-1 in the early epidemic. In order to characterize the demographic history of HIV-1 subtypes A and D in east Africa, we examined molecular epidemiology, geographical and historical data.

Methodology

We employed high-resolution phylodynamics to investigate the introduction of HIV-1A and D into east Africa, the geographic trends of viral spread, and the demographic growth of each subtype. We also used geographic information system data to investigate human migration trends, population growth, and human mobility.

Results

HIV-1A and D were introduced into east Africa after 1950 and spread exponentially during the 1970s, concurrent with eastward expansio

SUBMITTER: Gray RR 

PROVIDER: S-EPMC2742553 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature