[18F]fluorodeoxyglucose positron emission tomography for lung antiinflammatory response evaluation.

ABSTRACT:

Rationale

Few noninvasive biomarkers for pulmonary inflammation are currently available that can assess the lung-specific response to antiinflammatory treatments. Positron emission tomography with [(18)F]fluorodeoxyglucose (FDG-PET) is a promising new method that can be used to quantify pulmonary neutrophilic inflammation.

Objectives

To evaluate the ability of FDG-PET to measure the pulmonary antiinflammatory effects of hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) and recombinant human activated protein C (rhAPC) in a human model of experimentally-induced lung inflammation.

Methods

Eighteen healthy volunteers were randomized to receive placebo, lovastatin, or rhAPC before intrabronchial segmental endotoxin challenge. FDG-PET imaging was performed be

SUBMITTER: Chen DL 

PROVIDER: S-EPMC2742744 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature