MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family.

ABSTRACT: Signals that control the fine balance between cell death and cell survival are altered during tumorigenesis. Understanding the mechanisms by which this balance is perturbed, leading to excessive cell survival, is important for designing effective therapies. Proteins belonging to the B-cell lymphoma (BCL) family are known to regulate death responses to apoptotic signals, especially those originating within cells. A subset of BCL family members capable of inhibiting cell death is known to contribute to tumorigenesis; however, it is not known whether all six antiapoptotic BCL family members play a causal role in tumor development. Using a mouse model of MYC-driven leukemia, we showed that, in addition to the well characterized BCL2 and BCLxl (BCL2L1), the other four family members -- BCLw (BC

SUBMITTER: Beverly LJ 

PROVIDER: S-EPMC2743088 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature