Escitalopram and problem-solving therapy for prevention of poststroke depression: a randomized controlled trial.

ABSTRACT:

Context

Depression occurs in more than half of patients who have experienced a stroke. Poststroke depression has been shown in numerous studies to be associated with both impaired recovery in activities of daily living and increased mortality. Prevention of depression thus represents a potentially important goal.

Objective

To determine whether treatment with escitalopram or problem-solving therapy over the first year following acute stroke will decrease the number of depression cases that develop compared with placebo medication.

Design, setting, and participants

A multisite randomized controlled trial for prevention of depression among 176 nondepressed patients was conducted within 3 months following acute stroke from July 9, 2003, to October 1, 2007. The 12-month tr

SUBMITTER: Robinson RG 

PROVIDER: S-EPMC2743160 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature