Estrogen/estrogen receptor alpha signaling in mouse posterofrontal cranial suture fusion.

ABSTRACT:

Background

While premature suture fusion, or craniosynostosis, is a relatively common condition, the cause is often unknown. Estrogens are associated with growth plate fusion of endochondral bones. In the following study, we explore the previously unknown significance of estrogen/estrogen receptor signaling in cranial suture biology.

Methodology/principal findings

Firstly, estrogen receptor (ER) expression was examined in physiologically fusing (posterofrontal) and patent (sagittal) mouse cranial sutures by quantitative RT-PCR. Next, the cranial suture phenotype of ER alpha and ER beta knockout (alphaERKO, betaERKO) mice was studied. Subsequently, mouse suture-derived mesenchymal cells (SMCs) were isolated; the effects of 17-beta estradiol or the estrogen antagonist Fulvestr

SUBMITTER: James AW 

PROVIDER: S-EPMC2743190 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature