Tumour necrosis factor gene polymorphism: a predictive factor for the development of post-transplant lymphoproliferative disease.

ABSTRACT:

Background

Epstein-Barr virus-positive post-transplant lymphoproliferative disease (PTLD) is a potentially lethal complication of iatrogenic immunosupression after transplantation. Predicting the development of PTLD allowing early and effective intervention is therefore of importance. Polymorphisms within cytokine genes are implicated in susceptibility to, and progression of, disease however the published data are often conflicting. We undertook investigation of polymorphic alleles within cytokine genes in PTLD and non-PTLD transplant cohorts to determine risk factors for disease.

Methods

SSP-PCR was used to analyse single nucleotide polymorphism within tumour necrosis factor (TNF)-alpha, interleukin- 1, -6, -10 and lymphotoxin-alpha genes. The TNF-alpha levels were measured

SUBMITTER: McAulay KA 

PROVIDER: S-EPMC2743368 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature