Transient neurites of retinal horizontal cells exhibit columnar tiling via homotypic interactions.

ABSTRACT: Sensory neurons with common functions are often nonrandomly arranged and form dendritic territories that show little overlap, or tiling. Repulsive homotypic interactions underlie such patterns in cell organization in invertebrate neurons. It is unclear how dendro-dendritic repulsive interactions can produce a nonrandom distribution of cells and their spatial territories in mammalian retinal horizontal cells, as mature horizontal cell dendrites overlap substantially. By imaging developing mouse horizontal cells, we found that these cells transiently elaborate vertical neurites that form nonoverlapping columnar territories on reaching their final laminar positions. Targeted cell ablation revealed that the vertical neurites engage in homotypic interactions that result in tiling of neighboring

SUBMITTER: Huckfeldt RM 

PROVIDER: S-EPMC2743396 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature