Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses.

ABSTRACT:

Objective

To assess associations between baseline values of four different circulating markers of inflammation and future risk of coronary heart disease, potential triggers of systemic inflammation (such as persistent infection), and other markers of inflammation.

Design

Nested case-control comparisons in a prospective, population based cohort.

Setting

General practices in 18 towns in Britain.

Participants

506 men who died from coronary heart disease or had a non-fatal myocardial infarction and 1025 men who remained free of such disease until 1996 selected from 5661 men aged 40-59 years who provided blood samples in 1978-1980.

Main outcome measures

Plasma concentrations of C reactive protein, serum amyloid A protein, and serum albumin and leucocyte count

SUBMITTER: Danesh J 

PROVIDER: S-EPMC27435 | biostudies-literature | 2000 Jul

REPOSITORIES: biostudies-literature