Androgen receptors in a cichlid fish, Astatotilapia burtoni: structure, localization, and expression levels.

ABSTRACT: Androgens are an important output of the hypothalamic-pituitary-gonadal (HPG) axis that controls reproduction in all vertebrates. In male teleosts two androgens, testosterone and 11-ketotestosterone, control sexual differentiation and development in juveniles and reproductive behavior in adults. Androgenic signals provide feedback at many levels of the HPG axis, including the hypothalamic neurons that synthesize and release gonadotropin-releasing hormone 1 (GnRH1), but the precise cellular site of androgen action in the brain is not known. Here we describe two androgen receptor subtypes, ARalpha and ARbeta, in the cichlid Astatotilapia burtoni and show that these subtypes are differentially located throughout the adult brain in nuclei known to function in the control of reproduction. ARalp

SUBMITTER: Harbott LK 

PROVIDER: S-EPMC2743600 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature