Meta-analysis of glioblastoma multiforme versus anaplastic astrocytoma identifies robust gene markers.

ABSTRACT:

Background

Anaplastic astrocytoma (AA) and its more aggressive counterpart, glioblastoma multiforme (GBM), are the most common intrinsic brain tumors in adults and are almost universally fatal. A deeper understanding of the molecular relationship of these tumor types is necessary to derive insights into the diagnosis, prognosis, and treatment of gliomas. Although genomewide profiling of expression levels with microarrays can be used to identify differentially expressed genes between these tumor types, comparative studies so far have resulted in gene lists that show little overlap.

Results

To achieve a more accurate and stable list of the differentially expressed genes and pathways between primary GBM and AA, we performed a meta-analysis using publicly available genome-scale

SUBMITTER: Dreyfuss JM 

PROVIDER: S-EPMC2743637 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature