Extracting biologically significant patterns from short time series gene expression data.

ABSTRACT:

Background

Time series gene expression data analysis is used widely to study the dynamics of various cell processes. Most of the time series data available today consist of few time points only, thus making the application of standard clustering techniques difficult.

Results

We developed two new algorithms that are capable of extracting biological patterns from short time point series gene expression data. The two algorithms, ASTRO and MiMeSR, are inspired by the rank order preserving framework and the minimum mean squared residue approach, respectively. However, ASTRO and MiMeSR differ from previous approaches in that they take advantage of the relatively few number of time points in order to reduce the problem from NP-hard to linear. Tested on well-defined short time expre

SUBMITTER: Tchagang AB 

PROVIDER: S-EPMC2743670 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature