Parallel routes of human carcinoma development: implications of the age-specific incidence data.

ABSTRACT:

Background

The multi-stage hypothesis suggests that cancers develop through a single defined series of genetic alterations. This hypothesis was first suggested over 50 years ago based upon age-specific incidence data. However, recent molecular studies of tumors indicate that multiple routes exist to the formation of cancer, not a single route. This parallel route hypothesis has not been tested with age-specific incidence data.

Methodology/principal findings

To test the parallel route hypothesis, I formulated it in terms of a mathematical equation and then tested whether this equation was consistent with age-specific incidence data compiled by the Surveillance Epidemiology and End Results (SEER) cancer registries since 1973. I used the chi-squared goodness of fit test to meas

SUBMITTER: Brody JP 

PROVIDER: S-EPMC2743810 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature