Ontology highlight
ABSTRACT:
SUBMITTER: Townsend JA
PROVIDER: S-EPMC2743854 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Townsend Jeffrey A JA Wright David A DA Winfrey Ronnie J RJ Fu Fengli F Maeder Morgan L ML Joung J Keith JK Voytas Daniel F DF
Nature 20090429 7245
An efficient method for making directed DNA sequence modifications to plant genes (gene targeting) is at present lacking, thereby frustrating efforts to dissect plant gene function and engineer crop plants that better meet the world's burgeoning need for food, fibre and fuel. Zinc-finger nucleases (ZFNs)-enzymes engineered to create DNA double-strand breaks at specific loci-are potent stimulators of gene targeting; for example, they can be used to precisely modify engineered reporter genes in pl ...[more]