Long-living growth hormone receptor knockout mice: potential mechanisms of altered stress resistance.

ABSTRACT: Endocrine mutant mice have proven invaluable toward the quest to uncover mechanisms underlying longevity. Growth hormone (GH) and insulin-like growth factor (IGF) have been shown to be key players in physiological systems that contribute to aging processes including glucose metabolism, body composition and cellular protection. Examination of these mutant mice across several laboratories has revealed that differences exist in both the direction and magnitude of change, differences that may result in variation in life span. Growth hormone receptor knockout mice lack a functional GH receptor, therefore GH signaling is absent. These mice have been shown to lack the heightened oxidative defense mechanisms observed in other GH mutants yet live significantly longer than wild type mice. In this st

SUBMITTER: Brown-Borg HM 

PROVIDER: S-EPMC2743895 | biostudies-literature | 2009 Jan-Feb

REPOSITORIES: biostudies-literature