Multiple Notch signaling events control Drosophila CNS midline neurogenesis, gliogenesis and neuronal identity.

ABSTRACT: The study of how transcriptional control and cell signaling influence neurons and glia to acquire their differentiated properties is fundamental to understanding CNS development and function. The Drosophila CNS midline cells are an excellent system for studying these issues because they consist of a small population of diverse cells with well-defined gene expression profiles. In this paper, the origins and differentiation of midline neurons and glia were analyzed. Midline precursor (MP) cells each divide once giving rise to two neurons; here, we use a combination of single-cell gene expression mapping and time-lapse imaging to identify individual MPs, their locations, movements and stereotyped patterns of division. The role of Notch signaling was investigated by analyzing 37 midline-expres

SUBMITTER: Wheeler SR 

PROVIDER: S-EPMC2744345 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature