Association of single-nucleotide polymorphisms in JAK3, STAT4, and STAT6 with new cardiovascular events in incident dialysis patients.

ABSTRACT:

Background

Increasing evidence supports a role for cell-mediated immunity in the pathogenesis of cardiovascular disease. Single-nucleotide polymorphisms (SNPs) in JAK3, STAT4, and STAT6 of the Janus kinase-signal transducer and activator of transcription (Jak-Stat) signal transduction pathway were examined for association with time to new cardiovascular events in incident dialysis patients from the Choices for Healthy Outcomes in Caring for End-Stage Renal Disease Study.

Study design

Prospective cohort study.

Setting & participants

764 white (n = 518) and black (n = 246) participants from 79 dialysis centers.

Predictor

SNPs in JAK3, STAT4, and STAT6 selected using a pairwise approach to identify a maximally informative set of tag SNPs for populations of Europea

SUBMITTER: Sperati CJ 

PROVIDER: S-EPMC2744364 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature