Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis.

ABSTRACT: The mammalian circadian system has been implicated in the regulation of various biological processes including those involved in genotoxic stress responses and tumor suppression. Here we report that mice with the functional deficiency in circadian transcription factor CLOCK (Clock/Clock mutant mice) do not display predisposition to tumor formation both during their normal lifespan or when challenged by gamma- radiation. This phenotype is consistent with high apoptotic and low proliferation rate in lymphoid tissues of Clock mutant mice and is supported by the gene expression profiling of a number of apoptosis and cell cycle-related genes, as well as by growth inhibition of cells with CLOCK downregulation. At the same time, Clock mutant mice respond to low-dose irradiation by accelerating th

SUBMITTER: Antoch MP 

PROVIDER: S-EPMC2744375 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature