Protective effect of delayed treatment with low-dose glibenclamide in three models of ischemic stroke.

ABSTRACT:

Background and purpose

Ischemia/hypoxia induces de novo expression of the sulfonylurea receptor 1-regulated NC(Ca-ATP) channel. In rodent models of ischemic stroke, early postevent administration of the sulfonylurea, glibenclamide, is highly effective in reducing edema, mortality, and lesion volume, and in patients with diabetes presenting with ischemic stroke, pre-event plus postevent use of sulfonylureas is associated with better neurological outcome. However, the therapeutic window for treatment with glibenclamide has not been studied.

Methods

We examined the effect of low-dose (nonhypoglycemogenic) glibenclamide in 3 rat models of ischemic stroke, all involving proximal middle cerebral artery occlusion (MCAo): a thromboembolic model, a permanent suture occlusion model, a

SUBMITTER: Simard JM 

PROVIDER: S-EPMC2744391 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature