MicroRNA expression profiling of eutopic secretory endometrium in women with versus without endometriosis.

ABSTRACT: Endometriosis is a common gynecologic disorder characterized by pain and infertility. In addition to estrogen dependence, progesterone resistance is an emerging feature of this disorder. Specifically, a delayed transition from the proliferative to secretory phase as evidenced by dysregulation of progesterone target genes and maintenance of a proliferative molecular fingerprint in the early secretory endometrium (ESE) has been reported. MicroRNAs (miRNAs) are small noncoding RNAs that collectively represent a novel class of regulators of gene expression. In an effort to investigate further the observed progesterone resistance in the ESE of women with endometriosis, we conducted array-based, global miRNA profiling. We report distinct miRNA expression profiles in the ESE of women with versus

SUBMITTER: Burney RO 

PROVIDER: S-EPMC2744474 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature