Ontology highlight
ABSTRACT:
SUBMITTER: Migliaccio AR
PROVIDER: S-EPMC2744572 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Blood 20090701 10
Rigorously defined reconstitution assays developed in recent years have allowed recognition of the delicate relationship that exists between hematopoietic stem cells and their niches. This balance ensures that hematopoiesis occurs in the marrow under steady-state conditions. However, during development, recovery from hematopoietic stress and in myeloproliferative disorders, hematopoiesis occurs in extramedullary sites whose microenvironments are still poorly defined. The hypomorphic Gata1(low) m ...[more]