Feeding rapidly stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing translation initiation.

ABSTRACT: Food consumption increases protein synthesis in most tissues by promoting translation initiation, and in the neonate, this increase is greatest in skeletal muscle. In this study, we aimed to identify the currently unknown time course of changes in the rate of protein synthesis and the activation of factors involved in translation in neonatal muscle after a meal. After overnight food deprivation, 36 5- to 7-d-old piglets were administered a nutritionally complete bolus i.g. meal and were killed immediately before or 30, 60, 90, 120, or 240 min later. The increase in skeletal muscle protein synthesis peaked 30 min after the meal and this was sustained through 120 min, returning to baseline thereafter. The relative proportion of polysomes to nonpolysomes was higher only after 30 min. Protein

SUBMITTER: Wilson FA 

PROVIDER: S-EPMC2744610 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature