Energy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptor.

ABSTRACT:

Background

Homozygosity for 2 protein-altering polymorphisms in the melanocortin-3 receptor gene (MC3R) coding sequence, C17A and G241A, has been reported to be associated with an obesity phenotype in children, yet how these polymorphisms affect energy homeostasis is unknown. Association between adult body weight and +2138InsCAGACC, another variant in the 3' untranslated region of MC3R, has also been described.

Objective

The objective of this study was to examine associations of C17A + G241A and +2138InsCAGACC MC3R variants with children's energy balance.

Design

Children aged 6-19 y were genotyped for MC3R C17A, G241A, and +2138InsCAGACC. Subjects underwent studies of energy intake from a 9835-kcal food array (n = 185), resting energy expenditure (REE) by using indire

SUBMITTER: Savastano DM 

PROVIDER: S-EPMC2744620 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature