Smoking reduction with oral nicotine inhalers: double blind, randomised clinical trial of efficacy and safety.

ABSTRACT:

Objectives

To determine whether use of an oral nicotine inhaler can result in long term reduction in smoking and whether concomitant use of nicotine replacement and smoking is safe.

Design

Double blind, randomised, placebo controlled trial. Four month trial with a two year follow up.

Setting

Two university hospital pulmonary clinics in Switzerland.

Participants

400 healthy volunteers, recruited through newspaper advertisements, willing to reduce their smoking but unable or unwilling to stop smoking immediately.

Intervention

Active or placebo inhaler as needed for up to 18 months, with participants encouraged to limit their smoking as much as possible.

Main outcome measures

Number of cigarettes smoked per day from week six to end point. Decrease ve

SUBMITTER: Bolliger CT 

PROVIDER: S-EPMC27447 | biostudies-literature | 2000 Aug

REPOSITORIES: biostudies-literature