Pathologic and biologic response to preoperative endocrine therapy in patients with ER-positive ductal carcinoma in situ.

ABSTRACT:

Background

Endocrine therapy is commonly recommended in the adjuvant setting for patients as treatment for ductal carcinoma in situ (DCIS). However, it is unknown whether a neoadjuvant (preoperative) anti-estrogen approach to DCIS results in any biological change. This study was undertaken to investigate the pathologic and biomarker changes in DCIS following neoadjuvant endocrine therapy compared to a group of patients who did not undergo preoperative anti-estrogenic treatment to determine whether such treatment results in detectable histologic alterations.

Methods

Patients (n = 23) diagnosed with ER-positive pure DCIS by stereotactic core biopsy were enrolled in a trial of neoadjuvant anti-estrogen therapy followed by definitive excision. Patients on hormone replacement the

SUBMITTER: Chen YY 

PROVIDER: S-EPMC2744704 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature