Serum insulin, glucose, indices of insulin resistance, and risk of prostate cancer.

ABSTRACT:

Background

The mitogenic and growth-stimulatory effects of insulin-like growth factors appear to play a role in prostate carcinogenesis, yet any direct association of circulating insulin levels and risk of prostate cancer remains unclear.

Methods

We investigated the relationship of the level of serum insulin, glucose, and surrogate indices of insulin resistance (ie, the molar ratio of insulin to glucose and the homeostasis model assessment of insulin resistance [HOMA-IR]) to the development of prostate cancer in a case-cohort study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort of Finnish men. We studied 100 case subjects with incident prostate cancer and 400 noncase subjects without prostate cancer from the larger cohort. Fasting serum was collect

SUBMITTER: Albanes D 

PROVIDER: S-EPMC2744728 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature