Long-term effect of modification of dietary protein intake on the progression of diabetic nephropathy: a randomised controlled trial.

ABSTRACT:

Aims/hypothesis

There is currently insufficient evidence to recommend a low-protein diet for type 2 diabetic patients with diabetic nephropathy. We assessed whether a low-protein diet could prevent the progression of diabetic nephropathy.

Methods

This was a multi-site parallel randomised controlled trial for prevention of diabetic nephropathy progression among 112 Japanese type 2 diabetic patients with overt nephropathy. It was conducted in Japan from 1 December 1997 to 30 April 2006. The participants were randomly assigned using a central computer-generated schedule to either low-protein diet (0.8 g kg(-1) day(-1)) and normal-protein diet (1.2 g kg(-1) day(-1)), and were followed for 5 years. The participants and investigators were not blinded to the assignment. The primary

SUBMITTER: Koya D 

PROVIDER: S-EPMC2744830 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature