Low-resolution structural studies of human Stanniocalcin-1.

ABSTRACT:

Background

Stanniocalcins (STCs) represent small glycoprotein hormones, found in all vertebrates, which have been functionally implicated in Calcium homeostasis. However, recent data from mammalian systems indicated that they may be also involved in embryogenesis, tumorigenesis and in the context of the latter especially in angiogenesis. Human STC1 is a 247 amino acids protein with a predicted molecular mass of 27 kDa, but preliminary data suggested its di- or multimerization. The latter in conjunction with alternative splicing and/or post-translational modification gives rise to forms described as STC50 and "big STC", which molecular weights range from 56 to 135 kDa.

Results

In this study we performed a biochemical and structural analysis of STC1 with the aim of obtaining l

SUBMITTER: Trindade DM 

PROVIDER: S-EPMC2744999 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature