Repair of DNA lesions associated with triplex-forming oligonucleotides.

ABSTRACT: Triplex-forming oligonucleotides (TFOs) are gene targeting tools that can bind in the major groove of duplex DNA in a sequence-specific manner. When bound to DNA, TFOs can inhibit gene expression, can position DNA-reactive agents to specific locations in the genome, or can induce targeted mutagenesis and recombination. There is evidence that third strand binding, alone or with an associated cross-link, is recognized and metabolized by DNA repair factors, particularly the nucleotide excision repair pathway. This review examines the evidence for DNA repair of triplex-associated lesions.

SUBMITTER: Chin JY 

PROVIDER: S-EPMC2745299 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature