Systems integration of biodefense omics data for analysis of pathogen-host interactions and identification of potential targets.

ABSTRACT: The NIAID (National Institute for Allergy and Infectious Diseases) Biodefense Proteomics program aims to identify targets for potential vaccines, therapeutics, and diagnostics for agents of concern in bioterrorism, including bacterial, parasitic, and viral pathogens. The program includes seven Proteomics Research Centers, generating diverse types of pathogen-host data, including mass spectrometry, microarray transcriptional profiles, protein interactions, protein structures and biological reagents. The Biodefense Resource Center (www.proteomicsresource.org) has developed a bioinformatics framework, employing a protein-centric approach to integrate and support mining and analysis of the large and heterogeneous data. Underlying this approach is a data warehouse with comprehensive protein + g

SUBMITTER: McGarvey PB 

PROVIDER: S-EPMC2745575 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature