Pairwise and higher-order correlations among drug-resistance mutations in HIV-1 subtype B protease.

ABSTRACT:

Background

The reaction of HIV protease to inhibitor therapy is characterized by the emergence of complex mutational patterns which confer drug resistance. The response of HIV protease to drugs often involves both primary mutations that directly inhibit the action of the drug, and a host of accessory resistance mutations that may occur far from the active site but may contribute to restoring the fitness or stability of the enzyme. Here we develop a probabilistic approach based on connected information that allows us to study residue, pair level and higher-order correlations within the same framework.

Results

We apply our methodology to a database of approximately 13,000 sequences which have been annotated by the treatment history of the patients from which the samples were o

SUBMITTER: Haq O 

PROVIDER: S-EPMC2745583 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature