An integrated approach to the interpretation of single amino acid polymorphisms within the framework of CATH and Gene3D.

ABSTRACT:

Background

The phenotypic effects of sequence variations in protein-coding regions come about primarily via their effects on the resulting structures, for example by disrupting active sites or affecting structural stability. In order better to understand the mechanisms behind known mutant phenotypes, and predict the effects of novel variations, biologists need tools to gauge the impacts of DNA mutations in terms of their structural manifestation. Although many mutations occur within domains whose structure has been solved, many more occur within genes whose protein products have not been structurally characterized.

Results

Here we present 3DSim (3D Structural Implication of Mutations), a database and web application facilitating the localization and visualization of single a

SUBMITTER: Izarzugaza JM 

PROVIDER: S-EPMC2745587 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature