Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes.

ABSTRACT: The enormous toll on human life during the 1918-1919 Spanish influenza pandemic is a constant reminder of the potential lethality of influenza viruses. With the declaration by the World Health Organization of a new H1N1 influenza virus pandemic, and with continued human cases of highly pathogenic H5N1 avian influenza virus infection, a better understanding of the host response to highly pathogenic influenza viruses is essential. To this end, we compared pathology and global gene expression profiles in bronchial tissue from macaques infected with either the reconstructed 1918 pandemic virus or the highly pathogenic avian H5N1 virus A/Vietnam/1203/04. Severe pathology was observed in respiratory tissues from 1918 virus-infected animals as early as 12 hours after infection, and pathology stea

SUBMITTER: Cilloniz C 

PROVIDER: S-EPMC2745659 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature