Diastereoselective synthesis of cyclopentapyridazinones via radical cyclization: synthetic studies toward halichlorine.

ABSTRACT: The pyridazinone ring system serves as an excellent scaffold for the diastereoselective preparation of novel cis-fused cyclopentapyridazinones utilizing the directed 5-exo radical cyclization approach. This overall approach was successfully employed in the preparation of a functionalized aza-spirocycle.

SUBMITTER: Keck GE 

PROVIDER: S-EPMC2745910 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature