Improvement after constraint-induced movement therapy is independent of infarct location in chronic stroke patients.

ABSTRACT:

Background and purpose

Disruption of the corticospinal tract at various locations in the brain has been shown to predict worse spontaneous motor recovery after stroke. However, the anatomic specificity of previous findings was limited by the categorical classification of infarct locations. Here we used computational methods to more precisely determine the specific anatomic locations associated with impaired motor ability. More important, however, our study also used these techniques to evaluate whether infarct location could influence motor outcomes after Constraint-Induced Movement therapy (CI therapy), a specific and controlled form of physical therapy.

Methods

Quantitative voxel-based analyses were used to determine whether infarct location could predict either initial mo

SUBMITTER: Gauthier LV 

PROVIDER: S-EPMC2745936 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature