Efficient, selective, and green: catalyst tuning for highly enantioselective reactions of ethylene.

ABSTRACT: Fine tuning of the biaryl and amino moieties of Feringa's phosphoramidite ligands yields structurally simpler, yet more efficient and selective, ligands for asymmetric hydrovinylation of vinylarenes and acylic 1,3-dienes. The enantioselectivities and yields observed in the formation of the 3-arylbutenes are among the highest for all asymmetric catalytic processes reported to date for the synthesis of intermediates for the widely used antiinflammatory 2-arylpropionic acids including naproxen, ibuprofen, fenoprofen, and flurbiprofen.

SUBMITTER: Smith CR 

PROVIDER: S-EPMC2746057 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature