Augmented D1 dopamine receptor signaling and immediate-early gene induction in adult striatum after prenatal cocaine.

ABSTRACT:

Background

Prenatal exposure to cocaine can impede normal brain development, triggering a range of neuroanatomical and behavioral anomalies that are evident throughout life. Mouse models have been especially helpful in delineating neuro-teratogenic consequences after prenatal exposure to cocaine. The present study employed a mouse model to investigate alterations in D(1) dopamine receptor signaling and downstream immediate-early gene induction in the striatum of mice exposed to cocaine in utero.

Methods

Basal, forskolin-, and D(1) receptor agonist-induced cyclic adenosine monophosphate (cAMP) levels were measured ex vivo in the adult male striatum in mice exposed to cocaine in utero. Further studies assessed cocaine-induced zif 268 and homer 1 expression in the striatum of j

SUBMITTER: Tropea TF 

PROVIDER: S-EPMC2746072 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature