Curled encodes the Drosophila homolog of the vertebrate circadian deadenylase Nocturnin.

ABSTRACT: Drosophila melanogaster curled, one of the first fly mutants described by T. H. Morgan >90 years ago, is the founding member of a series of curled wing phenotype mutants widely used as markers in fruit fly genetics. The expressivity of the wing phenotype is environmentally modulated, suggesting that the mutation affects the metabolic status of cells rather than a developmental control gene. However, the molecular identity of any of the curled wing marker mutant genes is still unknown. In a screen for starvation-responsive genes, we previously identified the single fly homolog of the vertebrate nocturnin genes, which encode cytoplasmic deadenylases that act in the post-transcriptional control of genes by poly(A) tail removal of target mRNAs prior to their degradation. Here we show that curl

SUBMITTER: Gronke S 

PROVIDER: S-EPMC2746146 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature