Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival times.

ABSTRACT:

Background

Gene expression profiling of spontaneous tumors in the dog offers a unique translational opportunity to identify prognostic biomarkers and signaling pathways that are common to both canine and human. Osteosarcoma (OS) accounts for approximately 80% of all malignant bone tumors in the dog. Canine OS are highly comparable with their human counterpart with respect to histology, high metastatic rate and poor long-term survival. This study investigates the prognostic gene profile among thirty-two primary canine OS using canine specific cDNA microarrays representing 20,313 genes to identify genes and cellular signaling pathways associated with survival. This, the first report of its kind in dogs with OS, also demonstrates the advantages of cross-species comparison with human O

SUBMITTER: Selvarajah GT 

PROVIDER: S-EPMC2746177 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature