Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis.

ABSTRACT:

Background

Cell surface heparan sulfate proteoglycans (HSPGs) act as co-receptors for multiple families of growth factors that regulate animal cell proliferation, differentiation and patterning. Elimination of heparan sulfate during brain development is known to produce severe structural abnormalities. Here we investigate the developmental role played by one particular HSPG, glypican-1 (Gpc1), which is especially abundant on neuronal cell membranes, and is the major HSPG of the adult rodent brain.

Results

Mice with a null mutation in Gpc1 were generated and found to be viable and fertile. The major phenotype associated with Gpc1 loss is a highly significant reduction in brain size, with only subtle effects on brain patterning (confined to the anterior cerebellum). The brain

SUBMITTER: Jen YH 

PROVIDER: S-EPMC2746204 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature