Ptf1a is expressed transiently in all types of amacrine cells in the embryonic zebrafish retina.

ABSTRACT:

Background

The vertebrate retina is composed of five major types of neurons: three excitatory (photoreceptors, bipolar cells and ganglion cells) and two inhibitory (horizontal and amacrine cells). The transcription factor Ptf1a (pancreas transcription factor 1a) is important for the normal development of the inhibitory retinal neurons.

Results

Using a transgenic Ptf1a:GFP reporter and in situ hybridization in the zebrafish retina, we show that ptf1a message is transiently expressed in all amacrine and horizontal cells within hours after the terminal division of multipotent progenitors at the apical surface of the retinal neuroepithelium, and remains on as these cells migrate to their final laminar location. The message then shuts off, but we can follow the stable Ptf1a:GFP p

SUBMITTER: Jusuf PR 

PROVIDER: S-EPMC2746205 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature