Catalytic asymmetric stetter reaction onto vinylphosphine oxides and vinylphosphonates.

ABSTRACT: An intramolecular Stetter reaction of vinylphosphine oxides and vinylphosphonates has been developed. Treatment of an aldehyde with a nucleophilic N-heterocyclic carbene catalyst allows for addition of an acyl anion equivalent into a vinylphosphine oxide or vinylphosphonate Michael acceptor in yields up to 99% and ee values up to 96%.

SUBMITTER: Cullen SC 

PROVIDER: S-EPMC2746454 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature