Hsp70 structure, function, regulation and influence on yeast prions.

ABSTRACT: Heat shock proteins protect cells from various conditions of stress. Hsp70, the most ubiquitous and highly conserved Hsp, helps proteins adopt native conformation or regain function after misfolding. Various co-chaperones specify Hsp70 function and broaden its substrate range. We discuss Hsp70 structure and function, regulation by co-factors and influence on propagation of yeast prions.

SUBMITTER: Sharma D 

PROVIDER: S-EPMC2746719 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature