Evolutionary history of selenocysteine incorporation from the perspective of SECIS binding proteins.

ABSTRACT:

Background

The co-translational incorporation of selenocysteine into nascent polypeptides by recoding the UGA stop codon occurs in all domains of life. In eukaryotes, this event requires at least three specific factors: SECIS binding protein 2 (SBP2), a specific translation elongation factor (eEFSec), selenocysteinyl tRNA, and a cis-acting selenocysteine insertion sequence (SECIS) element in selenoprotein mRNAs. While the phylogenetic relationships of selenoprotein families and the evolution of selenocysteine usage are well documented, the evolutionary history of SECIS binding proteins has not been explored.

Results

In this report we present a phylogeny of the eukaryotic SECIS binding protein family which includes SBP2 and a related protein we herein term SBP2L. Here we show

SUBMITTER: Donovan J 

PROVIDER: S-EPMC2746813 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature