Genetic interactions between the Drosophila tumor suppressor gene ept and the stat92E transcription factor.

ABSTRACT:

Background

Tumor Susceptibility Gene-101 (TSG101) promotes the endocytic degradation of transmembrane proteins and is implicated as a mutational target in cancer, yet the effect of TSG101 loss on cell proliferation in vertebrates is uncertain. By contrast, Drosophila epithelial tissues lacking the TSG101 ortholog erupted (ept) develop as enlarged undifferentiated tumors, indicating that the gene can have anti-growth properties in a simple metazoan. A full understanding of pathways deregulated by loss of Drosophila ept will aid in understanding potential links between mammalian TSG101 and growth control.

Principal findings

We have taken a genetic approach to the identification of pathways required for excess growth of Drosophila eye-antennal imaginal discs lacking ept. We fin

SUBMITTER: Gilbert MM 

PROVIDER: S-EPMC2747001 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature