Genetic variation in sodium-dependent ascorbic acid transporters and risk of gastric cancer in Poland.

ABSTRACT: Higher ascorbic acid consumption is associated with a reduced risk of gastric cancer in numerous epidemiologic studies. We investigated whether single nucleotide polymorphisms (SNPs) in SLC23A1 and SLC23A2--genes that encode key ascorbic acid transport proteins--affect gastric cancer risk in 279 incident cases and 414 age- and gender-matched controls drawn from a population-based case-control study in Poland. Compared to subjects who were homozygous for the common G allele of the SLC23A2 SNP rs12479919, carriers of the AA genotype had a 41% lower risk of gastric cancer [odds ratio (OR)=0.59, 95% confidence interval (CI): 0.36-0.95; P trend=0.06]. A haplotype that contained the common allele of the rs6139591, rs2681116 and rs14147458 SNPs in SLC23A2 was also significantly inversely associat

SUBMITTER: Wright ME 

PROVIDER: S-EPMC2747493 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature