Genetic variation in the transforming growth factor-beta1 gene is associated with susceptibility to IgA nephropathy.

ABSTRACT:

Background

There is growing evidence of genetic risk for susceptibility to IgA nephropathy. Among several candidate genes related to immunological regulation in renal tissue, TGFB1 is known to be a contributor to proliferation and the development of fibrosis.

Methods

We analysed several SNPs in a region of this gene using 212 DNA samples from biopsy-proven IgA nephropathy patients, 146 men and 66 women and 477 healthy age-matched controls (321 men and 156 women) from the same population in Sweden.

Results

Frequencies of four out of five selected SNPs (rs6957, rs2241715, rs1800471, rs1982073 and rs1800469) were found to significantly differ between male patients and male controls in a co-dominant model (corrected P

SUBMITTER: Vuong MT 

PROVIDER: S-EPMC2747497 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature