Enantioselective synthesis of (+)-chamaecypanone C: a novel microtubule inhibitor.

ABSTRACT: A bicycle built for tubulin: The total synthesis of (+)-chamaecypanone C has been achieved by using a tandem retro-Diels-Alder/Diels-Alder cascade reaction (see scheme). Initial biological studies demonstrate that (+)-chamaecypanone C is an inhibitor of tubulin assembly and binds at the colchicine site.

SUBMITTER: Dong S 

PROVIDER: S-EPMC2747729 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature