Aberrant regulation of choline metabolism by mitochondrial electron transport system inhibition in neuroblastoma cells.

ABSTRACT: Anomalous choline metabolic patterns have been consistently observed in vivo using Magnetic Resonance Spectroscopy (MRS) analysis of patients with neurodegenerative diseases and tissues from cancer patient. It remains unclear; however, what signaling events may have triggered these choline metabolic aberrancies. This study investigates how changes in choline and phospholipid metabolism are regulated by distinct changes in the mitochondrial electron transport system (ETS). We used specific inhibitors to down regulate the function of individual protein complexes in the ETS of SH-SY5Y neuroblastoma cells. Interestingly, we found that dramatic elevation in the levels of phosphatidylcholine metabolites could be induced by the inhibition of individual ETS complexes, similar to in vivo observatio

SUBMITTER: Baykal AT 

PROVIDER: S-EPMC2747765 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature